About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913,City of Hopehas grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis fornumerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, andtreatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includesTranslational Genomics Research InstituteandAccessHope^TM. For more information about City of Hope, follow us onFacebook,Twitter,YouTube,InstagramandLinkedIn.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

Dr. Yanhong Shi’s lab is looking for highly motivated and productive postdoctoral fellows for stem cell research projects within the Department of Stem Cell Biology and Regenerative Medicine (Shi laboratory) at Beckman Research Institute of City of Hope located in the county of Los Angeles, California. Candidates interested in this position are encouraged to submit curriculum vitae, brief statement of interests and a list of three references.

The Shi laboratory has been well known for stem cell research, including stem cell-based disease modeling and cell therapy development. This laboratory is one of the pioneers in establishing disease models and cell therapies using the human induced pluripotent stem cell (iPSC) platform and has published extensively in this area. Some of the papers published by the Shi laboratories include Shi et al. Nature Reviews Drug Discovery 16: 115-130, 2017; Li et al. Cell Stem Cell 23: 239-251, 2018; Feng et al. Advanced Science 7: 2002155, 2020; Wang, et al. Cell Stem Cell 28: 331-342.e5, 2021; Chen et al. Advanced Science: 8: e2101462, 2021; Cui et al. Nature Cancer 2: 932-949, 2021.

The Shi laboratory has established protocols for differentiating human iPSCs into a variety of cell types, including brain cells, blood cells, and organoids, and has developed cellular models and cell therapeutic candidates for diseases including Alzheimer’s disease, Canavan disease, and glioblastoma. The Shi laboratory has well-established experimental platform and sufficient funding for candidates who are interested in doing first-class science.

Key Responsibilities include:

• The postdoctoral fellow will lead a project on human iPSC-based disease modeling and therapeutic development for neurological disorders such as Alzheimer’s disease.
• Fellows are expected to write progress reports and high-quality manuscripts for publication. Applying for postdoctoral fellowship and participating in grant applications are encouraged.
• Candidates should be highly motivated, have excellent interpersonal and communication skills, and multi-tasking skill.

Basic education, experience and skills required for consideration:

• A Ph.D. degree in life or biomedical sciences, or a related discipline is required.

Preferred education, experience and skills:

• A Ph.D., M.D. & Ph.D., or equivalent in biomedical research, with experience in cell culture and basic molecular biology.
• Experience with human iPSC culture, CRISPR/Cas9-mediated gene editing, neural differentiation of human iPSCs is a plus. Strong molecular biology background is preferred.

Additional information:

• For more information about Dr. Yanhong Shi’s lab, please visit here.
• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.