Research Assistant I Lab

Harvard Medical School

Boston, MA

Job posting number: #7104119

Posted: June 27, 2022

Application Deadline: Open Until Filled

Job Description

Position Description

The Brugge lab has a long-standing interest in understanding the mechanisms underlying cancer initiation and the development of therapy resistance using innovative techniques. For this project, we are interested in understanding why lung tumors with certain genetic mutations are highly resistant to immunotherapies and chemotherapy, with the ultimate goal to help improve treatment strategies for patients. We are looking for a highly motivated research assistant to join our team. As a research assistant, you will be working on projects that investigate the mechanisms of lung cancer resistance to immunotherapy and chemotherapy using both standard and three-dimensional cell culture systems, advanced genetically engineered mouse models (GEMMs) and syngeneic mouse models, under direct supervision and mentorship of a senior postdoctoral fellow. Former research assistants in the lab have co-authored high-impact publications and have successfully moved on to MD and/or PhD programs as well as industry positions.


TECHNICAL DUTIES AND RESPONSIBILITIES:
Design and optimize a tumor - immune cell co-culture system to investigate the molecular interactions between these cell types and their effects on therapy responsiveness;
Evaluate the effects of different drugs on the tumor immune response in syngeneic mouse models or GEMMs;
Perform regular mouse genotyping experiments, mouse colony maintenance and mouse tumor induction;
Carry out cell and tissue immunostaining, microscopy, and image analysis;
Run flow cytometry and FACS cell sorting;
Perform standard molecular biology techniques, e.g., plasmid cloning, gene expression and knockdown, qRT-PCR, western blots;
Assist in the design of laboratory experiments, techniques, and protocols;
May instruct other staff and students in basic laboratory techniques;
Perform related laboratory maintenance such as maintaining and cleaning equipment and ordering supplies;
Maintain accurate and detailed records of experimental results.

Basic Qualifications

College Background and at least 1 year of relevant experience.

Additional Qualifications and Skills

Bachelor's degree in biological sciences or related field strongly preferred.
Minimum 1 year experience in a research laboratory setting strongly preferred.
Experience in one or more of the following is preferred: mouse handling, cell culture, microscopy.
Highly motivated, good work ethic, and able to work independently and as a team.
Follow protocols with attention to detail.
Produce accurate and high-quality work.
Think creatively to solve problems.
Excellent skills in communication, organization, and time management.
Must be willing to make a two-year commitment, depending on work performance and funding.

Additional Information

This is a two-year term position from the date of hire, with the possibility of extension, contingent upon work performance and continued funding to support the position.

Offer contingent upon successful completion of a pre-placement medical evaluation.

This is an in-person position based on our campus in Boston.

The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard’s Vaccine & Booster Requirements. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/.

Please note that we are currently conducting a majority of interviews and onboarding remotely and virtually. We appreciate your understanding.

Harvard University offers an outstanding benefits package including:
Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 12.5 paid holidays, and 3 paid personal days per year.
Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
Retirement: University-funded retirement plan with full vesting after 3 years of service.
Tuition Assistance Program: Competitive tuition assistance program, incredibly affordable classes directly at the Harvard Extension School, and discounted options through participating Harvard grad schools.
Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.
Harvard access to athletic facilities, libraries, campus events, and many discounts throughout metro Boston.
The Harvard Medical School is not able to provide visa sponsorship for this position.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.


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