Senior Researcher I

Harvard Medical School

Boston, MA

Job posting number: #7101933

Posted: June 10, 2022

Application Deadline: Open Until Filled

Job Description

Position Description

We are looking for skilled and ambitious individuals excited to unlock next-generation gene therapy-based cures for previously incurable genetic disorders.


Our laboratory at Harvard Medical School is starting a new project whose mission is to pioneer the next generation of gene therapy vectors with programmable specificity and transgene expression. We employ PESCA1, a single-cell screening platform developed in-house, to sift through the mammalian genome and identify regulatory elements capable of driving optimal patterns of transgene expression to address a wide range of diseases. In collaboration with industry partners, we develop new extensions of the PESCA platform to advance our ability to create gene therapy vectors with precisely controlled expression in any desired cell type.

We are recruiting a full-time Research Scientist to join our team, whose primary responsibility will be to collaboratively develop and drive multiple iterations of the PESCA pipeline simultaneously. Day-to-day responsibilities include supervising and managing 1-2 research assistants, as well as interpreting and troubleshooting experimental results, to ensure continued progress on all projects. The work involves application of cutting-edge single-cell genomic technologies and interested applicants should be sufficiently experienced in wet lab work such that they can capably perform all steps of the PESCA pipeline. The position requires coordination of existing industry partnerships and multitasking to keep simultaneously ongoing projects on track. We are seeking highly motivated individuals with strong scientific backgrounds capable of efficient experimental planning, delegation, and management, who are excited by the prospect of pushing multiple projects to completion in a fast-paced academic setting. The position will report directly to our core group of scientific leadership, offering a unique opportunity to play a lead role in developing promising new viral vectors of high therapeutic potential as part of a highly collaborative and dynamic research group.

Collaboratively develop and strategically drive multiple implementations of the PESCA platform under supervision of core scientific leadership
Supervise, advise, and train research assistants who will perform bench experiments
Prepare daily experimental schedules and delegate tasks across team
Troubleshoot experiments or results and advise next steps
Use formal scheduling tools to ensure team coordination
Prioritize experiments with dynamic and flexible thinking and continuous evaluation of experimental quality and rigor
Coordinate with industry partners
Compose written project update summaries and present update slide decks
Report to core PESCA team leadership
Share insights for platform improvement and optimization

Basic Qualifications

PhD in biological sciences, molecular biology, genomics, neuroscience, or related discipline
4+ years hands-on wet lab experience

Additional Qualifications and Skills

Interested individuals should be capable of performing all steps of the PESCA pipeline, including:
Next-generation sequencing library preparation and analysis (bulk and single-cell ATAC-seq and RNA-seq)
Molecular biology techniques, including qPCR, RT-qPCR, molecular cloning, immunofluorescence, and RNA in situ hybridization.
Cell culture
AAV purification and delivery
Mouse handling and colony maintenance
Strong organizational and documentation skills
Good time management and rigorous scheduling, as multiple projects must progress simultaneously
Good interpersonal and collaborative skills to maintain a friendly and professional working environment
Strong scientific communication skills to keep project supervisors informed and present data to academic and industry collaborators
Experience managing multiple high-budget projects in industry or academic setting

Additional Information

This is a 12-month term appointment with the possibility of renewal contingent on funding.

Offer contingent upon successful completion of a pre-placement medical evaluation.

This is an in-person position based on our campus in Boston.

The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard’s Vaccine & Booster Requirements. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage:

Please note that we are currently conducting a majority of interviews and onboarding remotely and virtually. We appreciate your understanding.

Harvard University offers an outstanding benefits package including:
Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 12.5 paid holidays, and 3 paid personal days per year.
Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
Retirement: University-funded retirement plan with full vesting after 3 years of service.
Tuition Assistance Program: Competitive tuition assistance program, incredibly affordable classes directly at the Harvard Extension School, and discounted options through participating Harvard grad schools.
Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.
Harvard access to athletic facilities, libraries, campus events, and many discounts throughout metro Boston.
The Harvard Medical School is not able to provide visa sponsorship for this position.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.

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