Post doctoral researcher in genetically engineered T cell therapies at the University of Pennsylvania
Job posting number: #7089494
Posted: November 19, 2021
Application Deadline: Open Until Filled
Job DescriptionWe are seeking a full-time post-doctoral researcher for a fully funded NIH project aiming to develop allogeneic universal CAR T cell therapies. Our lab focuses on generating next generation CAR T cell therapies for patients with solid and liquid cancers. Situated within the University of Pennsylvania's School of Veterinary Medicine, the lab takes advantage of pet dogs with spontaneous cancers to evaluate the safety and efficacy of next-gen CAR technologies in canine clinical trials. We are looking for a talented post doctoral fellow to develop allogeneic CART cells using CRISPR technology and investigate the abillity of single chain trimers (SCT) to prevent NK-mediated elimination. The successful candidate will optimize gene transfer into primary canine immune cells, design and test the protective effects of SCT against NK cytotoxicity and perform functional analysis of re-directed, antigen-specific, gene edited canine CAR T cells. Immunological evaluation of pet dogs with naturally occurring cancers who receive next generation allogeneic CAR-T cells in clinical trials will be performed. The successful candidate will not be required to perform any clinical work with the canine patients. All pets on clinical trials are treated at the University of Pennsylvania's School of Veterinary Medicine by board certified veterinarians. We are seeking a motivated and talented translational immunologist to help advance our canine CAR T cell program in collaboration with several human CAR T cell laboratories at the University of Pennsylvania’s School of Medicine. The successful candidate will also have the opportunity to collaborate with colleagues across the University of Pennsylvania’s campus taking full advantage of the rich scientific surroundings and the specific expertise in CAR T cell technology that exists at this institution. The position is fully funded for 4 years through a collaborative U54 award with Dr. Carl June.