postdoctoral fellowship on the tumor microenvironment

MD Anderson Cancer Center

houston, TX

Job posting number: #7071939

Posted: November 8, 2020

Job Description

The Kurie Laboratory in the Department of Thoracic/Head and Neck Medical Oncology, MD Anderson Cancer Center, seeks to fill multiple postdoctoral positions. Our research focuses on the molecular mechanisms by which lung cancer cells generate a pro-metastatic tumor microenvironment, with three complementary areas of investigation: (1) a tumor cell-derived collagen modifying enzyme called lysyl hydroxylase 2 (LH2) that functions as a nodal regulator of fibrosis and immunosuppression; (2) Golgi-directed secretory processes driven by oncogene-induced transcriptional programs; and (3) epithelial-to-mesenchymal transition as a driver of fibrosis and immunosuppression in the tumor microenvironment.
Postdoctoral fellows will benefit from training in model development and characterization, including 2- and 3-dimensional cell culture models and autochthonous and orthotopic mouse models that recapitulate features of the TME in human cancers, and translating those findings to clinically and molecularly annotated human tumor tissue banks. Fellows will have educational and mentoring opportunities (e.g., pilot funding, grant-writing courses, and teaching and mentoring experience in our summer undergraduate and graduate internship programs) and extensive opportunities to gain presentation skills at weekly Kurie lab meetings, monthly departmental joint lab meetings, monthly meetings for our programmatic research groups (NCI-funded SPORE, CPRIT-funded MIRA), and annual conferences (e.g., Keystone, Gordon, Cold Spring Harbor, AACR).

Qualified individuals will demonstrate the potential for research as evidenced by their peer-reviewed publications and funding. Background in cancer biology and expertise in the design and execution of cell culture and in vivo experiments that incorporate a variety of molecular and cellular techniques is desirable. To apply, applicants must be eligible to work full-time in the U.S. and should email their CV including the names of three references to

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